A novel and Emerging Coronavirus Infection: Repurposing and Scale of Advances of Therapeutics, Imunotherapeutics and Vaccine Development, Tapas Kumar Mohapatra, Reena Rani Nayak, Arijit Mondal, Sitansu Sekhar Nanda, Drug Discovery 2021, 15(35),23-50.
Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751, Karen V. Lithgow, Brigette Church, Alloysius Gomez, et al., mSphere Apr 2020.
A Monoclonal Antibody to M-Phase Phosphoprotein 1/Kinesin-Like Protein KIF20B, Marvin J. Fritzler, Rachael D. Brown, Miefang Zhang, Scientific Reports, 2019.
Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection, J. Sweere et al., Science 2019.
Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy, M.A.H.M. Michels, et al., Frontiers in Immunology, 2019.
Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain, M. van Eijk, et al., Frontiers in Immunology, 2019.
Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b, R.M. van den Bos, et al., Frontiers in Immunology, 2019.
Tubuloids derived from human adult kidney and urine for personalized disease modeling, F. Schutgens, et al., Nature Biotechnology, 2019.
Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer’s Disease Mouse Model, A. Boutajangout, et al., Frontiers Aging Neuroscience, 2019.
A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing, F. Angiolini et al., eLife, 2019.
Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics, D.A.C. Heesterbeek, et al., Scientific Reports, 2019.
Analytical characterization and reference interval of an enzyme-linked immunosorbent assay for active von Willebrand factor, L.N. van der Vorm, et al., PLOS ONE, 2019.
Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases, D.A.C. Heesterbeek, et al., The EMBO Journal, 2019.
Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells, N. Fenderico, et al., Nature Communications,.
Structure and flexibility of the extracellular region of the PirB receptor, H.C. Vlieg, et al., JBC, 2019.
Human Norovirus Neutralized by a Monoclonal Antibody Targeting the Histo-Blood Group Antigen Pocket, Anna D. Koromyslova, Vasily A. Morozov, Losa Hefele, Grant S. Hansman, Journal of Virology 2018.
A Novel Sensitive Immunoassay Targeting the 5-Methylthio-d-Xylofuranose–Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis, George B Sigal, Abraham Pinter, Todd L. Lowary, et al., Journal of Clinical Microbiology, 2018.
Mix and match of the tumor metastasis suppressor Nm23protein isoformsin vitroandin vivo, C.M. Potel, et al., FEBS, 2018.
IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis, C. Steen-Louws, et al., Osteoarthritis and Cartilage, 2018.
Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade, C.A.W.Geuijen, et al., Cancer Cell, 2018..
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells, S. Liénart, et al., Science, 2018.
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels, S.A. Khetarpal, et al., Nature Medicine, 2017..
Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry, R.N.P. Rodenburg, et al., Nature Communications, 2017.
Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP), C. De Nardis, et al., Journal of Biological Chemistry, 2017.
A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation, C.C. Stobart, et al., Nature Communications, 2016.
Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies, C. Blanchetot, et al., JBC, 2016.
DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops, B. van der Woning, et al., mAbs vol. 8, no. 6, 1126–1135, 2016.
Depleting MET-Expressing Tumor Cells by ADCCProvides a Therapeutic Advantage over Inhibiting HGF/MET Signaling, A. Hultberg, et al., Cancer Research, 2015.
Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation, C.A. Diebolder, et al., Structure, 2015.
Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3), K.J. Koymans, et al., Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes, E.T. Berends, et al., BMC Biology, 2015.
Molecular imaging with a fluorescent antibody targeting carbonic anhydrase IX can successfully detect hypoxic ductal carcinoma in situ of the breast, A.S.A. van Brussel, et al., Breast Cancer Research and Treatment, 2013.
TLR Accessory Molecule RP105 (CD180) Is Involved in Post-Interventional Vascular Remodeling and Soluble RP105 Modulates Neointima Formation, J.C. Karper, et al., PLOS one, 2013
Near-Infrared Fluorescence Molecular Imaging of Ductal Carcinoma In Situ with CD44v6-Specific Antibodies in Mice: A Preclinical Study, J.F. Vermeulen, A.S.A. van Brussel, et al., Mol Imaging Biol., 2013, 15(3), 290 - 298.
Enhanced secretion of leukocyte‐associated immunoglobulin‐like receptor 2 (LAIR‐2) and soluble LAIR‐1 in rheumatoid arthritis: LAIR‐2 is a more efficient antagonist of the LAIR‐1–collagen inhibitory interaction than is soluble LAIR‐1, M.J.M. Olde Nordkamp, et al., Rheumatoid Arthritis, 2011.
Introduction of N-linked glycans in the lectin domain of surfactant protein D (SP-D): impact on interactions with influenza A viruses, M. van Eijk, et al., JBC, 286, 20137 - 20151.
The influenza A virus hemagglutinin glycosylation state affects receptor-binding specificity, R.P. de Vries, et al., Virology, 403, 17-25.
Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins, A. Garcia-Lopez, et al., Endocrinology, 151 (5), 2349-2360.
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor, S.H.M. Rooijakkers, et al., Nature Immunology, 10 (7), 721-729.
Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis, P.P. de Waal, et al., Journal of Endocrinology, 202, 287-297.
Staphylococcal SSL5 inhibits leukocyte activation by chemokines and anaphylatoxins, J. Bestebroer, et al., Blood, 113 (2), 328-337.
Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex, B.J.C. Janssen, et al., EMBO, 28, 2469-2478.
Staphylococcal Superantigen-like10 Inhibits CXCL12-Induced Human Tumor Cell Migration, A.M.E. Walenkamp, et al., Neoplasia 11 (4), 333-344.
Structure and functional relevance of the Slit2 homodimerization domain, E. Seiradake, et al., EMBO, 10, 736-741.
Surface-Plasmon-Resonance-Based Chemical Pteomics: Efficient Specific Extraction and Semiquantitative Identification of Cyclic Nucleotide-Binding Proteins from Cellular Lysates by Using a Combination of Surface Plasmon Resonance, Sequential Elution and Liquid Chromatography-Tandem Mass Spectrometry, N.F.C. Visser, et al., ChemBioChem, 8, 298 - 305.
Analysis of the cGMP/cAMP Interactome Using a Chemical Proteomics Approach in Mammalian Heart Tissue Validates phingosine Kinase Type 1-interacting Protein as a Genuine and Highly Abundant AKAP, Arjen Scholten, et al., Journal of Proteome Research 2006, 5, 1435-1447.
Characterization of bitiscetin-2, a second form of bitiscetin from the venom of Bitis arietans: comparison of its binding site with the collagen-binding site on the von Willebrand factor A3-domain, B. Obert, et al., Journal of Thrombosis and Haemostasis, 4, 1596-1601.