References

Products

    Antibodies


    2020


  • Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure, Damiana et al., Clin Chim Acta 2020.

  • 2019


  • Release of active peptidylarginine deiminase into the circulation during acute inflammation induced by coronary artery bypass surgery, Vejlstrup et al., J Inflamm Res. 2019.

  • Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis , Eldin et al., J Autoimmun 2019.

  • Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours, V. Martin, et al., British Journal of Cancer, 2019.

  • 2018


  • Augmentation of Myc-Dependent Mitotic Gene Expression by the Pygopus2 Chromatin Effector, Andrews et al., .

  • Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex,Park et al., Mol Cell 2018.

  • Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination, Zhou et al., Front Immunol 2018.

  • Pitfalls in the detection of citrullination and carbamylation, Verheul et al., Autoimmun Rev 2018.

  • Investigating The Anti-Inflammatory Activity of An Ethanolic Extract From Artocarpus Tonkinesis Leaves Using A Collagen Antibody-Induced Arthritic Mouse Model, Quan et al., Vietnam Journal of Science and Technology 2018 56(3) (2018)286-294.

  • 2017


  • Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase, Damgaard et al., J Enzyme Inhib Med Chem 2017.

  • Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils, Zhou et al., Front Immunol 2017.

  • Joint inflammation related citrullination of functional arginines in extracellular proteins, Sipilä et al., Sci Rep 2017.

  • Persistence of Disease associated anti-citrullinated protein memory B cells in rheumatoid arthritis persist in clinical remission, Pelzek et al., Arthritis Rheumatol 2017.

  • 2016


  • Spatiotemporal Expression of Endogenous TLR4 Ligands Leads to Inflammation and Bone Erosion in Mouse Collagen-Induced Arthritis, Wambiekele Kiyeko et al., Eur J Immunol 2016.

  • Extracellular citrullination inhibits the function of matrix associated TGF-β, Sipilä et al.,Matrix Biology 2016.

  • Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase, Damgaard et al., Arthritis Res Ther 2016.

  • Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers, Damgaard et al., Rheumatology 2016.

  • A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes , Karthikeyan et al., Mol Cell Proteomics 2016.

  • Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis, Schwenzer et al., Ann Rheum Dis 2016.

  • A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma, Cantarino et al., Int J Cancer 2016.

  • Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice, Suzuki et al., BMC Musculoskeletal Disorders 2016.

  • Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics, A. Klarenbeek et al., Protein Engineering, Design and Selection, 2016.

  • 2015


  • Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid, Spengler et al., Arthritis Rheumatol 2015.

  • 2014


  • Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen, Damgaard et al., Arthritis Res Ther 2014.

  • Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis, De Hair et al., Arthritis Rheumatol 2014.

  • 2013


  • Anti-Citrullinated Protein Antibodies as Novel Therapeutic Drugs in Rheumatoid Arthritis, Chirivi et al., J Clin Cell Immunol 2013

  • 2012


  • Cross‐reactivity of a human IgG1 anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide, Trier et al., Protein Science 2012.

  • Autoantibodies to αS1-Casein Are Induced by Breast-Feeding, Petermann et al., PLoS One. 2012; 7(4): e32716.

  • 2011

  • Casein a s1 Is Expressed by Human Monocytes and Upregulates the Production of GM-CSF via p38 MAPK, Vordenbäumen et al., Journal of Immunology 2011.

  • Viperin mRNA Is a Novel Target for the Human RNase MRP/RNase P Endoribonuclease, Mattijsen et al., Cell Mol Life Sci 2011.

  • Generation of novel recombinant antibodies against nitrotyrosine by antibody phage display, Hof et al., Human Antibodies 2011.

  • Clickable Enzyme-Linked Immunosorbent Assay, Canalle et al., Biomacromolecules 2011.

  • 2010


  • Dis3‐like 1: a novel exoribonuclease associated with the human exosome, Staals et al., EMBO J 2010.

  • 2008


  • Cartilage–hair hypoplasia-associated mutations in the RNase MRP P3 domain affect RNA folding and ribonucleoprotein assembly, Welting et al., Biochim Biophys Acta 2008.

  • 2007


  • ABAP: Antibody-Based Assay for Peptidylarginine Deiminase Activity, Zendman et al., Analytical Biochemistry 2007.

  • Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways, Van Dijk et al.,RNA 2007.

  • C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing, Schilders et al.,Nucleic Acids Res 2007.

  • Heterodimerization regulates RNase MRP/RNase P association, localization, and expression of Rpp20 and Rpp25, Welting et al., RNA 2007.

  • 2006


  • Differential association of protein subunits with the human RNase MRP and RNase P complexes, Welting et al., RNA 2006.

  • 2005


  • MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation, Schilders et al., Nucleic Acids Res 2005.

  • Proteins


    2020


  • Whole blood thrombin generation profiles of patients with cirrhosis explored with a near patient assay, J. Wan, et al., Journal of Thrombosis and Haemostasis, 2020.

  • 2019


  • Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis, K. Lloyd et al., Front. Immunol. 2019.

  • Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis , Eldin et al., J Autoimmun 2019.

  • Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts, A, Krishnamurthy et al., J Immunol 2019.

  • PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination, A.M. Falcao et al., Cell Reports 2019.

  • Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes, V.R. Wiersma et al., Int. J. Mol. Sci. 2019, 20(16), 4046.

  • Novel Aptamer To Von Willebrand Factor A1 Domain (TAGX-0004) Shows Total Inhibition Of Thrombus Formation Superior To ARC1779 And Comparable To Caplacizumab, K. Sakai, et al., Haematologica, 2019.

  • Role of GnRH isoforms in paracrine/autocrine control of zebrafish (Danio rerio) spermatogenesis, H.P. Fallah, et al., Endocrinology, 2019.

  • Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy, E. Driehuis, et al., Journal of Clinical Medicine, 2019.

  • Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study, M. Beugeling, et al., pharmaceutics, 2019.

  • Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy, E. Driehuis, et al., Cancer Discovery, 2019.

  • Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping, H.Gehart, et al., Cell, 2019.

  • 2018


  • Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis, J. Steen et al., Arthritis & Rheumatology 2018.

  • A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA, A. Wong et al., J Immunol April 1, 2018.

  • Bone morphogenetic protein-2 exhibits therapeutic benefits for osteonecrosis of the femoral head through induction of cartilage and bone cells, C. Wang et al., Experimental and Therapeutic Medicine 2018.

  • S87 Bronchiectasis relevant molecules promote NETosis and citrullination in human peripheral blood neutrophils, Scott J Davis et al., .

  • Peptidylarginine deiminase is involved in maintaining the cornified oral mucosa of rats, S. Arita et al., .

  • Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells, T Colasanti et al., .

  • Mass Spectrometry in the Determination of Glycosylation Site and N-Glycan Structures of Human Placental Alkaline Phosphatase, K. Solakyildirim, et al., Mass Spectrometry Letters, 2018.

  • Targeting the MET oncogene by concomitant inhibition of receptor and ligand via an antibody‐“decoy” strategy, C. Basilico, et al., International Journal of Cancer, 2018..

  • 2017


  • Platelet-rich plasma exhibits beneficial effects for rheumatoid arthritis mice by suppressing inflammatory factors, S. Tong et al., Molecular Medicine Reports 2017.

  • Platelet-rich plasma has beneficial effects in mice with osteonecrosis of the femoral head by promoting angiogenesis, S. Tong et al., Experimental and Therapeutic Medicine 2017.

  • Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis, S. Bettoni, et al., The Journal of Immunology, 2017.

  • 2016


  • Citrullination in the periodontium—a possible link between periodontitis and rheumatoid arthritis, O. Laugisch et al., Clinical Oral Investigations volume 20, pages675–683(2016).

  • Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies, M Sorice et al., Rheumatology Volume 55, Issue 8, August 2016.

  • Cross-species validation of cell cycle arrest markers for acute kidney injury in the rat during sepsis, Z. Peng, e al., Intensive Care Mediccine Experimental, 2016.

  • Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model, J. Li, et al.,PLoS ONE, 2016.

  • 2015


  • Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors, A. Trabocchi et al., Journal of Enzyme Inhibition and Medicinal Chemistry 2015.

  • Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes, D Rondas et al., Diabetes 2015 Feb; 64(2): 573-586.

  • Cross-species validation of cell cycle arrest markers for acute kidney injury in the rat during sepsis, Z.Y. Peng, et al., Intensive Care Medicine Experimental, 2015..

  • 2014


  • Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis, J. Koziel et al., J Immunol 2014.

  • Fibronectin is a serum biomarker for Duchennemuscular dystrophy, F.C Martin, et al., Proteomics Clinical Applications, 2014.

  • Adenovirus Composition, Proteolysis, and Disassembly Studied by In-depth Qualitative and Quantitative Proteomics, M. Benevento, et al., JBC 2014.

  • 2013


  • Immobilization of unraveled immunoglobulin G using well-oriented ZZ–His protein on functionalized microtiter plate for sensitive immunoassay, Yang et al., Analytical Biochem 2013

  • Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors, Bozdag et al., https://www.sciencedirect.com/science/article/abs/pii/S0960894X12015545

  • Plasma reference value of heart-type fatty acid-binding protein, the earliest available plasma biomarker of acute myocardial infarction, J.F.C Glatz, and R. Mohren, Health, 5 (8), 1206 - 1209.

  • Proteome-derived Peptide Libraries to Study the Substrate Specificity Profiles of Carboxypeptidases, S. Tanco, et al., Molecular and Cellular Proteomics, 2013, 12, 2096 - 2110.

  • Deep proteome profiling of Trichoplax adhaerens reveals remarkable features at the origin of metazoan multicellularity, J.H. Ringrose, et al., Nature Communications, 2013, 4, Article 1408.

  • 2012


  • Inactivation of Epidermal Growth Factor by Porphyromonas gingivalis as a Potential Mechanism for Periodontal Tissue Damage, K. Pyrc et al., Infection and Immunity Dec 2012.

  • Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo, B.M. Mohamed et al., Nanomedicine 2012.

  • 2011


  • Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro, M.L.B. Hillaire, et al., PloS ONE, 6 (9), e25005.

  • 2010


  • Novel amelanotic and melanotic cell lines NM78-AM and NM78-MM derived from a human oral malignant melanoma, T. Nakahara et al., Human Cell 2010.