Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils, Zhou et al., Front Immunol 2017.
Joint inflammation related citrullination of functional arginines in extracellular proteins, Sipilä et al., Sci Rep 2017.
Persistence of Disease associated anti-citrullinated protein memory B cells in rheumatoid arthritis persist in clinical remission, Pelzek et al., Arthritis Rheumatol 2017.
Spatiotemporal Expression of Endogenous TLR4 Ligands Leads to Inflammation and Bone Erosion in Mouse Collagen-Induced Arthritis, Wambiekele Kiyeko et al., Eur J Immunol 2016.
Extracellular citrullination inhibits the function of matrix associated TGF-β, Sipilä et al.,Matrix Biology 2016.
Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase, Damgaard et al., Arthritis Res Ther 2016.
Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers, Damgaard et al., Rheumatology 2016.
A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes
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Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis, Schwenzer et al., Ann Rheum Dis 2016.
A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma, Cantarino et al., Int J Cancer 2016.
Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid, Spengler et al., Arthritis Rheumatol 2015.
Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen, Damgaard et al., Arthritis Res Ther 2014.
Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis, De Hair et al., Arthritis Rheumatol 2014.
Anti-Citrullinated Protein Antibodies as Novel Therapeutic Drugs in
Rheumatoid Arthritis, Chirivi et al., J Clin Cell Immunol 2013
Cross‐reactivity of a human IgG1 anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide, Trier et al., Protein Science 2012.
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis, K. Lloyd et al., Front. Immunol. 2019.
Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis , Eldin et al., J Autoimmun 2019.
Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts, A, Krishnamurthy et al., J Immunol 2019.
PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination, A.M. Falcao et al., Cell Reports 2019.
Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes, V.R. Wiersma et al., Int. J. Mol. Sci. 2019, 20(16), 4046.
Novel Aptamer To Von Willebrand Factor A1 Domain (TAGX-0004) Shows Total Inhibition Of Thrombus Formation Superior To ARC1779 And Comparable To Caplacizumab, K. Sakai, et al., Haematologica, 2019.
Role of GnRH isoforms in paracrine/autocrine control of zebrafish (Danio rerio) spermatogenesis, H.P. Fallah, et al., Endocrinology, 2019.
Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy, E. Driehuis, et al., Journal of Clinical Medicine, 2019.
Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study, M. Beugeling, et al., pharmaceutics, 2019.
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy, E. Driehuis, et al., Cancer Discovery, 2019.
Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping, H.Gehart, et al., Cell, 2019.
Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis, J. Steen et al., Arthritis & Rheumatology 2018.
A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA, A. Wong et al., J Immunol April 1, 2018.