References

Products

    Antibodies


    2020


  • CBacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production, Jenning M, Marklein B, Ytterberg J, Zubarev RA, Joshua V, et al., Ann Rheum Dis. 2020 Sep;79(9):1194-1202..

  • Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis, Jäger, E., Murthy, S., Schmidt, C. et al., Nat Commun 11, 4243 (2020).

  • Polygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating proinflammatory cytokine production in mice, Huyen Do Thi Thanh, Phuong Ngo Thi, et al. Asian Pacific Journal of Tropical Biomedicine, 2020.

  • Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure, Damiana et al., Clin Chim Acta 2020.

  • 2019


  • Release of active peptidylarginine deiminase into the circulation during acute inflammation induced by coronary artery bypass surgery, Vejlstrup et al., J Inflamm Res. 2019.

  • Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis , Eldin et al., J Autoimmun 2019.

  • Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours, V. Martin, et al., British Journal of Cancer, 2019.

  • 2018


  • Augmentation of Myc-Dependent Mitotic Gene Expression by the Pygopus2 Chromatin Effector, Andrews et al., .

  • Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex,Park et al., Mol Cell 2018.

  • Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination, Zhou et al., Front Immunol 2018.

  • Pitfalls in the detection of citrullination and carbamylation, Verheul et al., Autoimmun Rev 2018.

  • Investigating The Anti-Inflammatory Activity of An Ethanolic Extract From Artocarpus Tonkinesis Leaves Using A Collagen Antibody-Induced Arthritic Mouse Model, Quan et al., Vietnam Journal of Science and Technology 2018 56(3) (2018)286-294.

  • 2017


  • Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase, Damgaard et al., J Enzyme Inhib Med Chem 2017.

  • Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils, Zhou et al., Front Immunol 2017.

  • Joint inflammation related citrullination of functional arginines in extracellular proteins, Sipilä et al., Sci Rep 2017.

  • Persistence of Disease associated anti-citrullinated protein memory B cells in rheumatoid arthritis persist in clinical remission, Pelzek et al., Arthritis Rheumatol 2017.

  • 2016


  • Spatiotemporal Expression of Endogenous TLR4 Ligands Leads to Inflammation and Bone Erosion in Mouse Collagen-Induced Arthritis, Wambiekele Kiyeko et al., Eur J Immunol 2016.

  • Extracellular citrullination inhibits the function of matrix associated TGF-β, Sipilä et al.,Matrix Biology 2016.

  • Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase, Damgaard et al., Arthritis Res Ther 2016.

  • Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers, Damgaard et al., Rheumatology 2016.

  • A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes , Karthikeyan et al., Mol Cell Proteomics 2016.

  • Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis, Schwenzer et al., Ann Rheum Dis 2016.

  • A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma, Cantarino et al., Int J Cancer 2016.

  • Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice, Suzuki et al., BMC Musculoskeletal Disorders 2016.

  • Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics, A. Klarenbeek et al., Protein Engineering, Design and Selection, 2016.

  • 2015


  • Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid, Spengler et al., Arthritis Rheumatol 2015.

  • 2014


  • Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen, Damgaard et al., Arthritis Res Ther 2014.

  • Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis, De Hair et al., Arthritis Rheumatol 2014.

  • 2013


  • Anti-Citrullinated Protein Antibodies as Novel Therapeutic Drugs in Rheumatoid Arthritis, Chirivi et al., J Clin Cell Immunol 2013

  • 2012


  • Cross‐reactivity of a human IgG1 anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide, Trier et al., Protein Science 2012.

  • Autoantibodies to αS1-Casein Are Induced by Breast-Feeding, Petermann et al., PLoS One. 2012; 7(4): e32716.

  • 2011

  • Casein a s1 Is Expressed by Human Monocytes and Upregulates the Production of GM-CSF via p38 MAPK, Vordenbäumen et al., Journal of Immunology 2011.

  • Viperin mRNA Is a Novel Target for the Human RNase MRP/RNase P Endoribonuclease, Mattijsen et al., Cell Mol Life Sci 2011.

  • Generation of novel recombinant antibodies against nitrotyrosine by antibody phage display, Hof et al., Human Antibodies 2011.

  • Clickable Enzyme-Linked Immunosorbent Assay, Canalle et al., Biomacromolecules 2011.

  • 2010


  • Dis3‐like 1: a novel exoribonuclease associated with the human exosome, Staals et al., EMBO J 2010.

  • 2008


  • Cartilage–hair hypoplasia-associated mutations in the RNase MRP P3 domain affect RNA folding and ribonucleoprotein assembly, Welting et al., Biochim Biophys Acta 2008.

  • 2007


  • ABAP: Antibody-Based Assay for Peptidylarginine Deiminase Activity, Zendman et al., Analytical Biochemistry 2007.

  • Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways, Van Dijk et al.,RNA 2007.

  • C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing, Schilders et al.,Nucleic Acids Res 2007.

  • Heterodimerization regulates RNase MRP/RNase P association, localization, and expression of Rpp20 and Rpp25, Welting et al., RNA 2007.

  • 2006


  • Differential association of protein subunits with the human RNase MRP and RNase P complexes, Welting et al., RNA 2006.

  • 2005


  • MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation, Schilders et al., Nucleic Acids Res 2005.

  • Proteins


    2021


  • Epithelial response to IFN-γ promotes SARS-CoV-2 infection, Heuberger J, Trimpert J, Vladimirova D, et al., EMBO Mol Med. 2021 Apr 9;13(4).

  • Conformation-Dependent Blockage of Activated VWF Improved Outcomes of Traumatic Brain Injury in Mice, Xin Xu, Chenyu Wang, Yingang Wu, et al., Blood 2021; 137(4):544-555.

  • Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells, Iftekhar, A., Berger, H., Bouznad, N. et al., Nat Commun 12, 1003 (2021).

  • Culture and analysis of kidney tubuloids andperfused tubuloid cells-on-a-chip, Gijzen, L., Yousef Yengej, F.A., Schutgens, F. et al., Nat Protoc 16, 2023-2050 (2021).

  • Molecular characterization and expression analysis of anti-Müllerian hormone in common carp (Cyprinus carpio) adult testes, Marcos A. Oliveira, Emanuel R.M. Martinez, Arno J. Butzge, et al., Gene Expression Patterns, Volume 40, 2021 (2021).

  • Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids, Dekkers, J.F., van Vliet, E.J., Sachs, N. et al. Nat Protoc 16, 1936-1965 (2021).

  • Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution, Georg A. Busslinger, Bas L.A. Weusten, Auke Bogte, et al., Cell Reports, Volume 34, Issue 10, 2021.

  • Exploring the human lacrimal gland using organoids and single-cell sequencing, Marie Bannier-Hélaouët, Yorick Post, Jeroen Korving, et al., Cell Stem Cell 2021.

  • Effects of gonadotropin-inhibitory hormone on early and late stages of spermatogenesis in ex-vivo culture of zebrafish testis, Fallah HP, Rodrigues MS, Zanardini M, Nóbrega RH, Habibi HR., Mol Cell Endocrinol. 2021 Jan 15;520:111087.

  • Neurotensin differentially regulates bile acid metabolism and intestinal FXR‐bile acid transporter axis in response to nutrient abundance, Jing Li, Jun Song, Baoxiang Yan, et al., The Faseb Journal, 2021.

  • 2020


  • Establishment of patient-derived cancer organoids for drug-screening applications, Driehuis, E., Kretzschmar, K. & Clevers, H., Nat Protoc 15, 3380–3409 (2020).

  • Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells, Cayetano Pleguezuelos‐Manzano, Jens Puschhof Stieneke van den Brink, Veerle Geurts, Joep Beumer, Hans Clevers, Current Protocols in in Immunology 2020.

  • Introducing the Stem Cell ASCL2 Reporter STAR into Intestinal Organoids, Maria C. Heinz, Koen C. Oost, Hugo J.G. Snippert, STAR Protocols, 2020.

  • Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo, Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, et al., Journal of Thrombosis and Haemostasis, 2020.

  • Whole blood thrombin generation profiles of patients with cirrhosis explored with a near patient assay, J. Wan, et al., Cell Stem Cell. 2020 Nov 5;27(5):840-851.

  • 2019


  • Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis, K. Lloyd et al., Front. Immunol. 2019.

  • Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis , Eldin et al., J Autoimmun 2019.

  • Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts, A, Krishnamurthy et al., J Immunol 2019.

  • PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination, A.M. Falcao et al., Cell Reports 2019.

  • Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes, V.R. Wiersma et al., Int. J. Mol. Sci. 2019, 20(16), 4046.

  • Novel Aptamer To Von Willebrand Factor A1 Domain (TAGX-0004) Shows Total Inhibition Of Thrombus Formation Superior To ARC1779 And Comparable To Caplacizumab, K. Sakai, et al., Haematologica, 2019.

  • Role of GnRH isoforms in paracrine/autocrine control of zebrafish (Danio rerio) spermatogenesis, H.P. Fallah, et al., Endocrinology, 2019.

  • Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy, E. Driehuis, et al., Journal of Clinical Medicine, 2019.

  • Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study, M. Beugeling, et al., pharmaceutics, 2019.

  • Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy, E. Driehuis, et al., Cancer Discovery, 2019.

  • Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping, H.Gehart, et al., Cell, 2019.

  • 2018


  • Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis, J. Steen et al., Arthritis & Rheumatology 2018.

  • A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA, A. Wong et al., J Immunol April 1, 2018.

  • Bone morphogenetic protein-2 exhibits therapeutic benefits for osteonecrosis of the femoral head through induction of cartilage and bone cells, C. Wang et al., Experimental and Therapeutic Medicine 2018.

  • S87 Bronchiectasis relevant molecules promote NETosis and citrullination in human peripheral blood neutrophils, Scott J Davis et al., .

  • Peptidylarginine deiminase is involved in maintaining the cornified oral mucosa of rats, S. Arita et al., .

  • Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells, T Colasanti et al., .

  • Mass Spectrometry in the Determination of Glycosylation Site and N-Glycan Structures of Human Placental Alkaline Phosphatase, K. Solakyildirim, et al., Mass Spectrometry Letters, 2018.

  • Targeting the MET oncogene by concomitant inhibition of receptor and ligand via an antibody‐“decoy” strategy, C. Basilico, et al., International Journal of Cancer, 2018..

  • 2017


    2017


  • PFlovobaterium spp., Thomas P. Loch and Mohamed Faisal, Fish Viruses and Bacteria Pathobiology and Protection 2017.

  • Platelet-rich plasma exhibits beneficial effects for rheumatoid arthritis mice by suppressing inflammatory factors, S. Tong et al., Molecular Medicine Reports 2017.

  • Platelet-rich plasma has beneficial effects in mice with osteonecrosis of the femoral head by promoting angiogenesis, S. Tong et al., Experimental and Therapeutic Medicine 2017.

  • Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis, S. Bettoni, et al., The Journal of Immunology, 2017.

  • 2016


  • Citrullination in the periodontium—a possible link between periodontitis and rheumatoid arthritis, O. Laugisch et al., Clinical Oral Investigations volume 20, pages675–683(2016).

  • Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies, M Sorice et al., Rheumatology Volume 55, Issue 8, August 2016.

  • Cross-species validation of cell cycle arrest markers for acute kidney injury in the rat during sepsis, Z. Peng, e al., Intensive Care Mediccine Experimental, 2016.

  • Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model, J. Li, et al.,PLoS ONE, 2016.

  • 2015


  • Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors, A. Trabocchi et al., Journal of Enzyme Inhibition and Medicinal Chemistry 2015.

  • Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes, D Rondas et al., Diabetes 2015 Feb; 64(2): 573-586.

  • Cross-species validation of cell cycle arrest markers for acute kidney injury in the rat during sepsis, Z.Y. Peng, et al., Intensive Care Medicine Experimental, 2015..

  • 2014


  • Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis, J. Koziel et al., J Immunol 2014.

  • Fibronectin is a serum biomarker for Duchennemuscular dystrophy, F.C Martin, et al., Proteomics Clinical Applications, 2014.

  • Adenovirus Composition, Proteolysis, and Disassembly Studied by In-depth Qualitative and Quantitative Proteomics, M. Benevento, et al., JBC 2014.

  • 2013


  • Immobilization of unraveled immunoglobulin G using well-oriented ZZ–His protein on functionalized microtiter plate for sensitive immunoassay, Yang et al., Analytical Biochem 2013

  • Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors, Bozdag et al., https://www.sciencedirect.com/science/article/abs/pii/S0960894X12015545

  • Plasma reference value of heart-type fatty acid-binding protein, the earliest available plasma biomarker of acute myocardial infarction, J.F.C Glatz, and R. Mohren, Health, 5 (8), 1206 - 1209.

  • Proteome-derived Peptide Libraries to Study the Substrate Specificity Profiles of Carboxypeptidases, S. Tanco, et al., Molecular and Cellular Proteomics, 2013, 12, 2096 - 2110.

  • Deep proteome profiling of Trichoplax adhaerens reveals remarkable features at the origin of metazoan multicellularity, J.H. Ringrose, et al., Nature Communications, 2013, 4, Article 1408.

  • 2012


  • Inactivation of Epidermal Growth Factor by Porphyromonas gingivalis as a Potential Mechanism for Periodontal Tissue Damage, K. Pyrc et al., Infection and Immunity Dec 2012.

  • Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo, B.M. Mohamed et al., Nanomedicine 2012.

  • 2011


  • Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro, M.L.B. Hillaire, et al., PloS ONE, 6 (9), e25005.

  • 2010


  • Novel amelanotic and melanotic cell lines NM78-AM and NM78-MM derived from a human oral malignant melanoma, T. Nakahara et al., Human Cell 2010.