Conformation-Dependent Blockage of Activated VWF Improved Outcomes of Traumatic Brain Injury in Mice, Xin Xu, Chenyu Wang, Yingang Wu, et al., Blood 2021; 137(4):544-555.
Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells, Iftekhar, A., Berger, H., Bouznad, N. et al., Nat Commun 12, 1003 (2021).
Culture and analysis of kidney tubuloids andperfused tubuloid cells-on-a-chip, Gijzen, L., Yousef Yengej, F.A., Schutgens, F. et al., Nat Protoc 16, 2023-2050 (2021).
Molecular characterization and expression analysis of anti-Müllerian hormone in common carp (Cyprinus carpio) adult testes, Marcos A. Oliveira, Emanuel R.M. Martinez, Arno J. Butzge, et al., Gene Expression Patterns, Volume 40, 2021 (2021).
Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids, Dekkers, J.F., van Vliet, E.J., Sachs, N. et al. Nat Protoc 16, 1936-1965 (2021).
Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution, Georg A. Busslinger, Bas L.A. Weusten, Auke Bogte, et al., Cell Reports, Volume 34, Issue 10, 2021.
Exploring the human lacrimal gland using organoids
and single-cell sequencing, Marie Bannier-Hélaouët, Yorick Post, Jeroen Korving, et al., Cell Stem Cell 2021.
Effects of gonadotropin-inhibitory hormone on early and late stages of spermatogenesis in ex-vivo culture of zebrafish testis, Fallah HP, Rodrigues MS, Zanardini M, Nóbrega RH, Habibi HR., Mol Cell Endocrinol. 2021 Jan 15;520:111087.
Neurotensin differentially regulates bile acid metabolism and intestinal FXR‐bile acid transporter axis in response to nutrient abundance, Jing Li, Jun Song, Baoxiang Yan, et al., The Faseb Journal, 2021.
Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production, Jenning M, Marklein B, Ytterberg J, Zubarev RA, Joshua V, et al., Ann Rheum Dis. 2020 Sep;79(9):1194-1202..
Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis, Jäger, E., Murthy, S., Schmidt, C. et al., Nat Commun 11, 4243 (2020).
Establishment of patient-derived cancer organoids for drug-screening applications, Driehuis, E., Kretzschmar, K. & Clevers, H., Nat Protoc 15, 3380–3409 (2020).
Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells, Cayetano Pleguezuelos‐Manzano, Jens Puschhof Stieneke van den Brink, Veerle Geurts, Joep Beumer, Hans Clevers, Current Protocols in in Immunology 2020.
Introducing the Stem Cell ASCL2 Reporter STAR into Intestinal Organoids, Maria C. Heinz, Koen C. Oost, Hugo J.G. Snippert, STAR Protocols, 2020.
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis, K. Lloyd et al., Front. Immunol. 2019.
Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis , Eldin et al., J Autoimmun 2019.
Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts, A, Krishnamurthy et al., J Immunol 2019.
PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination, A.M. Falcao et al., Cell Reports 2019.
Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes, V.R. Wiersma et al., Int. J. Mol. Sci. 2019, 20(16), 4046.
Novel Aptamer To Von Willebrand Factor A1 Domain (TAGX-0004) Shows Total Inhibition Of Thrombus Formation Superior To ARC1779 And Comparable To Caplacizumab, K. Sakai, et al., Haematologica, 2019.
Role of GnRH isoforms in paracrine/autocrine control of zebrafish (Danio rerio) spermatogenesis, H.P. Fallah, et al., Endocrinology, 2019.
Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy, E. Driehuis, et al., Journal of Clinical Medicine, 2019.
Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study, M. Beugeling, et al., pharmaceutics, 2019.
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy, E. Driehuis, et al., Cancer Discovery, 2019.
Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping, H.Gehart, et al., Cell, 2019.
Augmentation of Myc-Dependent Mitotic Gene Expression by the Pygopus2 Chromatin Effector, Andrews et al., Cell Reports 2018.
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex,Park et al., Mol Cell 2018.
Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination, Zhou et al., Front Immunol 2018.
Pitfalls in the detection of citrullination and carbamylation, Verheul et al., Autoimmun Rev 2018.
Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis, J. Steen et al., Arthritis & Rheumatology 2018.
A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA, A. Wong et al., J Immunol April 1, 2018.
Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis, S. Bettoni, et al., The Journal of Immunology, 2017.
Spatiotemporal Expression of Endogenous TLR4 Ligands Leads to Inflammation and Bone Erosion in Mouse Collagen-Induced Arthritis, Wambiekele Kiyeko et al., Eur J Immunol 2016.
Extracellular citrullination inhibits the function of matrix associated TGF-β, Sipilä et al.,Matrix Biology 2016.
Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase, Damgaard et al., Arthritis Res Ther 2016.
Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers, Damgaard et al., Rheumatology 2016.
A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes, Karthikeyan et al., Mol Cell Proteomics 2016.
Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis, Schwenzer et al., Ann Rheum Dis 2016.
A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma, Cantarino et al., Int J Cancer 2016.
Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model, J. Li, et al.,PLoS ONE, 2016.
Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid, Spengler et al., Arthritis Rheumatol 2015.
Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen, Damgaard et al., Arthritis Res Ther 2014.
Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis, De Hair et al., Arthritis Rheumatol 2014.
Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis, J. Koziel et al., J Immunol 2014.