End-to-End Services

End-to-End Services Overview

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Antibody Discovery

Proprietary and data-driven antibody discovery technologies feed our B cell Select™, phage display, and hybridoma generation using semi-solid media and clone picking, to deliver high affinity antibodies for your therapeutic pipeline.
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B cell Select

Our proprietary B cell screening, sorting, and sequencing technology increases the speed of antibody discovery, maintains native antibody pairing, provides antibodies of higher sensitivity and specificity and is applicable to any protein class, including complex therapeutic targets. Combining this technology with, for example, OmniAb® animals offers a truly unique and superior antibody discovery option not found elsewhere.

Rabbits

ImmunoPrecise offers rabbit monoclonal antibody development. Our proprietary technology allows for the screening of the immune repertoire of the rabbit, creating the power to select the desired antibody directly from the B cells using our B cell Select antibody discovery platform.

ModiFuse

The ModiFuse technology is based on our proprietary electrofusion platform for generating larger numbers of hybridomas compared to traditional fusions, which allows for rapid and efficient generation of monoclonal antibodies against virtually any target. This technique is combined with optimized immunization protocols, a wide variety of mouse and rat strains, and semi-automated screening facilities.

Semi-Solid Media & Clone Picking

ImmunoPrecise uses proprietary semi-solid media to grow mouse and rat hybridomas post-fusion. This special media allows for the support and picking of single cell colonies immediately after the fusion and hybridomas are essentially monoclonal from the start. No serial dilution (limiting dilution) cloning is required and all hybridomas that grow from the fusion can be tested for specific antibodies within two weeks post-fusion. The quick detection of antibody-specific clones allows for immediate subcloning and cryopreservation of valuable cultures.

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Phage Display

ImmunoPrecise is pleased to offer in-house and custom phage libraries. Our phage display approach is based on building custom immune libraries from multiple species, or the selection of antigen specific recombinant antibody fragments. Our proprietary libraries have been made from human patient and naïve (scFv) repertoires, as well as from naïve llama (VHH) repertoires. Custom immune libraries are prepared from blood, spleen, lymph nodes, and bone marrow of immunized animals or humans and capture the entire immune repertoire for panning, rescue, and identification of unique antibodies with pre-specified characteristics.

This advanced technology allows us to express antibody fragments in bacteria or rapidly reformat into any given Ig format, such as full-size IgG of various isotypes, bispecifics, Fc mutants to modify effector functions, or chimeras with Fc regions from different species.

DeepDisplay

A powerful new technology utilizing a combination of Ligand’s OmniAb® transgenic animal platform and ImmunoPrecise Antibodies’ custom phage display antibody selection.

See DeepDisplay™ poster for more details.

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