End-to-End Services

End-to-End Services Overview

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Characterization & Optimization

We provide services to characterize and optimize your valuable monoclonal antibody. Specificity testing in various assays can be complemented with affinity ranking of antibody panels or epitope mapping and binning using BLI-based platforms. After hybridoma sequencing, we can clone, reformat, affinity mature, chimerize, or humanize your antibody before we produce the antibody recombinantly at a quality and quantity of your choice.
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Antibody Sequencing

Your monoclonal antibody is extremely valuable, but hybridoma cell lines can become unstable over time and can stop secreting antibody. With ImmunoProtect™, the DNA sequence of your antibody will be determined and can be used to produce your antibody recombinantly.

Antibody Characterization

We provide highly purified, well-characterized, low endotoxin, or labeled antibodies for various applications. Additional services include affinity ranking of antibody panels or epitope mapping and binning using BLI-based platforms, as well as custom assay development.

Antibody Chimerization

We can clone and produce any variable antibody domain into any immunoglobulin context required, such as full-size mouse, rabbit, chicken, or human format, chimeras with any Fc region of choice, including effector mutants or Fc fusions.

Antibody Affinity Maturation

Antibody affinity is vital in therapeutic and diagnostic applications. ImmunoPrecise’s antibody affinity maturation service can improve antibody affinities by several fold. We apply different strategies to increase the affinity of your antibody, including gene shuffling and random mutagenesis.

Assay Development

ImmunoPrecise offers custom assay development services fully tailored to the needs of our clients. In addition, we have developed assays in-house (e.g., anti-TNF bioactivity assays, CAIA mouse model, etc.).

See available assays in our Products section.

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Antibody Humanization (LucinaTech)

Animal-derived monoclonal antibodies can elicit human anti-animal antibody responses in patients. Therefore, it is usually necessary to replace the animal content with the corresponding human amino acid residues. We provide a robust and efficient antibody humanization service, which consistently retains affinity and specificity levels. Our approach is based on state-of-the-art in silico antibody modeling to identify an essential framework and CDR residues for grafting onto a human antibody framework.

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